WebProtein Engineering vol.13 no.12 pp.849–856, 2000 PoPMuSiC, an algorithm for predicting protein mutant stability changes. Application to prion proteins Dimitri Gilis1 and Marianne Rooman Inge ... WebApr 11, 2024 · To further improve its enzymatic performance, two mutants of Q42V and I51H exhibiting both improved thermostability and enzyme activity were screened by the PoPMuSiC algorithm. Compared with the wild-type κ-carrageenase (WT), Q42V and I51H increased the enzyme activity by 20.9% and 25.4%, respectively.
PoPMuSiC, an algorithm for predicting protein mutant
WebA Variable Neighborhood Search Integrated in the POPMUSIC Framework 33 Algorithm 1. Basic POPMUSIC framework Input: Solution S composed of parts s 1,...,s p, parameter r Set A ←∅ while A = {s 1,...,s p} do Select seed part s i ∈/ A Create a sub-problem R i composed of the r parts s i1,...,s ir most related to s i Optimize R i if R i has ... WebMay 13, 2011 · PoPMuSiC-2.1 is a web server that predicts the thermodynamic stability changes caused by single site mutations in proteins, using a linear combination of … klay schools near me
(PDF) PoPMuSiC 2.1: A web server for the estimation of protein ...
WebMay 13, 2011 · PoPMuSiC 2.1: A web server for ... Gilis D, Rooman M: PoPMuSiC, an algorithm for Predicting Protein. Mutant Stability Changes. Application to prion proteins. … WebFeb 25, 2024 · Six publicly available predictors were explored in this study: FoldX , I-Mutant 3.0 , PoPMuSiC 2.1 , Maestro , mCSM and CUPSAT . The chosen methods use a variety of algorithms to compute the change in protein stability upon mutation: FoldX uses an empirical force field to calculate the free energy of folding for the wild-type and mutant … WebAug 3, 2009 · The parameters defining these sigmoid functions are identified with the help of a neural network, which is also an important novelty of our algorithm, PoPMuSiC-2.0. 2 … klay school ace app