Webb11 dec. 2024 · TSLP is mainly and constitutively produced by epithelial cells of the skin, gut and lungs, and shapes the response of dendritic cells and T cells against invading pathogens in a typical type 2 “weep and sweep” response that when misdirected, may also contribute to asthma and allergic inflammation ( 14 – 17 ). Webb24 feb. 2011 · Recent studies show that thymic stromal lymphopoietin (TSLP) plays an important role in the development of allergic disease . TSLP promotes the migration of myeloid DCs to the regional lymph nodes, and TSLP-activated DCs (TSLP-DCs) induce naive T cells to develop into the Th2 cells via OX40 ligand and OX40 co-stimulatory interactions .
Thymic Stromal Lymphopoietin - an overview ScienceDirect Topics
WebbTNF-related apoptosis-inducing ligand (TRAIL) promotes inflammation through upregulation of the E3 ubiquitin-ligase midline-1 (MID1), which binds to and deactivates … Webb29 mars 2024 · Summary This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c … unetgenerator\u0027 object has no attribute module
Mechanism of MARCH1 promotes OX40L expression JAA
WebbThymic stromal lymphopoietin (TSLP), an interleukin 7-like cytokine, can trigger dendritic cell (DC)-mediated T-helper type 2 (Th2) inflammatory responses. Recent evidence … WebbThymic stromal lymphopoietin (TSLP) is a newly identified cytokine that uniquely promotes B lymphopoiesis to the B220+/IgM+ immature B cell stage [9]. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5 [10]. Webb15 mars 2024 · Thymic stromal lymphopoietin (TSLP) is an epithetlial cell derived cytokine which has been reported to be a master regulator in T helper (Th) 2 driven inflammation. Through acting on dentritic cells (DCs), granulocytes, natural killer T cells or directly on CD4+ T cells, TSLP plays significant roles in the pathogenesis of atopic diseases … unethical 7