Topoisomerase 2 alpha

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August undefined, 2024

WebMay 22, 2013 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein ... WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor ...

Topoisomerase Inhibitors DrugBank Online

Webtopoisomerase (DNA) II alpha nucleus, response to DNA damage stimulus, nucleotide binding, nucleoplasm, ATP binding, protein complex, DNA binding, nucleolus, positive regulation of apoptotic process, protein homodimerization activity, drug binding, metal ion binding, magnesium ion binding, sequence-specific DNA binding, positive regulation of … WebNov 15, 2024 · Keith, W. N., Tan, K. B. & Brown, R. Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II ... glory beanie baby price

Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?

WebTopoisomerase Inhibitors. Compounds that inhibit the activity of DNA TOPOISOMERASES. A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. WebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been extensively studied in breast cancer patients treated with anthracyclines. However, results are not conclusive. In this paper, we review some of the published studies addressing ... WebProtein target information for DNA topoisomerase 2-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. bohol earthquake 2013 damage cost

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Topoisomerase 2 alpha

The prognostic significance of topoisomerase II alpha …

WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A introduces transient double strand breaks (DSB) on DNA in an ATP-dependent fashion to allow changes in DNA topology and eliminate over-winding [1,2]. TOP2A function is crucial … WebAbstract. Topoisomerase II is a key target for several anti-cancer drugs used for breast cancer therapy, including doxorubicin, epirubicin and mitoxantrone. Two isoforms of topoisomerase II (alpha and beta) have been described in human cells which differ in their subcellular localisation, biochemical properties and susceptibility to inhibition ...

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DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands … See more TOP2A has been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1, P53, and TOPBP1. See more In Drosophila Hadlaczky et al 1988 found DNA topoisomerase II α to correlate with cell proliferation - but β did not. See more • Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681 See more • Topoisomerase II • TOP2B - Topoisomerase II beta • Gene duplication • Ataxia-telangiectasia See more WebOct 13, 2024 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein on luminal breast cancer and its utility as an independent prognostic marker. Immunohistochemical expression of Top 2 A in breast …

WebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II … WebHuman Topoisomerase II Alpha Assay Conditions and Performance QC. Decatenation assays are carried out using kinetoplast DNA substrate in a final volume of 20-30 µl in topo II reaction buffer (50 mM Tris-Cl, pH 8.0, 120 mM KCl, 10 mM MgCl2. 0.5 mM ATP, 0.5 mM dithiothreitol) with 0.2 µg KDNA. Reactions are terminated with 5 µl (per 20 µl ...

WebJun 15, 2012 · To better understand how these enzymes act in both contexts, we determined the 2.9-Å-resolution structure of the DNA … WebNov 15, 2024 · Topoisomerase II alpha inhibition can overcome taxane-resistant prostate cancer through DNA repair pathways Download PDF Your article has downloaded

WebMar 19, 2024 · Here, we investigated the role of topoisomerase IIA (Top2α, an enzyme that is essential in resolving entangled DNA strands during replication) in telomeric DNA …

WebTopoisomerase II Alpha has been identified by DNA microarray and transcriptional profiling as a gene that is overexpressed in Cervical Carcinomas. The TOP2A gene is approximately 30 kb in size and encodes … bohol earthquake 2013 magnitudeWebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A … boho leather backpackWebControl of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. ... glory beans coffee house albemarle ncWebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small … bohol earthquake magnitudeWebApplications. Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (Primary incubation for 30 min at RT). Use at an assay dependent concentration. Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 174 kDa. glory be augusta scattergood pdfWebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small cell lung cancer (TOP2A) and brain metastasis operatively. The expression of MRP and TOP2A were performed using immunohistochemistry (IHC) staining, and the results were … bohol earthquake 2013 phivolcsWebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been … boho leather fringe sandals